In 1957, under the administration of 14th International President Arnetta G. Wallace, the International Region of Alpha Kappa Alpha Sorority, Incorporated®, was established. The first chapter in the region was Eta Beta Omega Chapter in Monrovia, Liberia, led by Anne E. Cooper. The sorority achieved distinction in the global arena with, Eta Beta Omega, having the first African woman to lead the UN General Assembly, Angie Brooks in 1969 and having the first woman to be elected Chief of State on the African continent, Ellen Johnson-Sirleaf, Liberian President in 2006.

With the ostentatious event of chartering the Eta Beta Omega chapter, it has led the sorority to charter chapters on four continents and islands in the Caribbean. The International Region held its first Regional Conference in Freeport, Bahamas in 1989. In 1996, under the administration of 24th International President, Eva Evans, the first two undergraduate chapters were chartered on the United States Virgin Islands of St. Croix and St. Thomas. The chapters Rho Xi and Rho Omicorn on the campuses of the University of the Virgin Islands.